Research Areas

3D Models of Lung Health and Disease

Our lab uses biomaterials and magnetic aggregation of microsphere templates with lung cells to make 3D models for studying how cellular and extracellular inputs influence lung disease initiation and progression.

Murine ATII cells in 3D hydrogel lung models

Stem Cells for Studying Lung Disease and Repair

Human induced pluripotent stem cells (iPSCs) are a source of human cells that our lab differentiates into alveolar epithelial cells and grows within 3D biomaterial models to study lung disease and repair.

Human ATII cells derived from iPSCs

Hydrogel-Embedded Precision Cut Lung Slices

In collaboration with Dr. Meredith Tennis, we have engineered ex vivo models of lung cancer by exposing hydrogel-embedded precision-cut lung slices (PCLS) to common carcinogens found in cigarette smoke. We can use these models to study new drug treatments.

Cellular proliferation in hydrogel-embedded PCLS exposed to carcinogens

Phototunable Hydrogel Biomaterials

The Magin Lab invents, synthesizes, and characterizes phototunable hydrogel biomaterials that can be engineered to support 2D and 3D cell culture, may include proteins from decellularized tissues, and can dynamically mimic changes in lung mechanical properties.

Phototunable hybrid-hydrogels for studying pulmonary fibrosis

Sex Differences in Pulmonary Arterial Hypertension

Our lab 3D prints realistic models of pulmonary blood vessels using biomaterials that start out with the same stiffness as healthy blood vessels and can be stiffened to replicate scarring. We use these models to study differences between female and male patients at the cellular and molecular levels.

Confocal microscope images of 3D-printed vascular mimics