Bio-inspired 3D microenvironments: a new dimension in tissue engineering

Chelsea M Magin, Daniel L Alge and Kristi S Anseth. 2016. Biomed. Mater, 11 022001 (link)

To emphasize the potential clinical impact of the bio-inspired paradigm in biomaterials engineering, some applications of bio-inspired matrices are discussed in the context of translational tissue engineering. However, focus is also given to recent advances in the use of engineered 3D cellular microenvironments for fundamental studies in cell biology, including photoresponsive systems that are shedding new light on how matrix properties influence cell phenotype and function. 

Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing

Chelsea M. Magin, Dylan B. Neale, Michael C. Drinker, Bradley J. Willenberg, Shravanthi T. Reddy, Krista MD La Perle, Gregory S. Schultz and Anthony B. Brennan. 2016. Exp Biol Med (Maywood)241(9): 986-95 (link)

Here, a bilayered, biodegradable hydrogel dressing that uses microarchitecture to guide two key steps in the proliferative phase of wound healing, re-epithelialization, and revascularization, was evaluated in vitro in a cell migration assay and in vivo in a bipedicle ischemic rat wound model. Collectively, the results demonstrate high potential for this new dressing to effectively accelerate wound healing.

Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model

Chelsea M. Magin, Rhea M. May, Michael C. Drinker, Kevin H. Cuevas, Anthony B. Brennan and Shravanthi T. Reddy. 2015. Translational Vision Science and Technology4(2): 1-8 (link)

A novel intraocular lens (IOL) incorporating the Sharklet (SK) micropattern in a membrane design surrounding the optic may help increase the success of cataract surgery by reducing secondary cataract, or posterior capsule opacification (PCO).


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