Tissue-Informed Engineering Strategies for Modeling Human Pulmonary Diseases
Kolene E. Bailey, Michael L. Floren, Tyler J. D’Ovidio, Steven R. Lammers, Kurt R. Stenmark, and Chelsea M. Magin. 2018. Am J Physiol Lung Cell Mol Physiol, doi: 10.1152/ajplung/00353.2018 (link)
This review highlights how advances in lung tissue characterization reveal dynamic changes in the structure, mechanics and composition of the extracellular matrix in chronic pulmonary diseases, and how this information paves the way for tissue-informed engineering of more organotypic models of human pathology. Current translational challenges are discussed as well as opportunities to overcome these barriers with precision biomaterial design and advanced biomanufacturing techniques that embody the principles of personalized medicine to facilitate the rapid development of novel therapeutics for this devastating group of chronic diseases.
Bio-inspired 3D microenvironments: a new dimension in tissue engineering
Chelsea M Magin, Daniel L Alge and Kristi S Anseth. 2016. Biomed. Mater, 11 022001 (link)
To emphasize the potential clinical impact of the bio-inspired paradigm in biomaterials engineering, some applications of bio-inspired matrices are discussed in the context of translational tissue engineering. However, focus is also given to recent advances in the use of engineered 3D cellular microenvironments for fundamental studies in cell biology, including photoresponsive systems that are shedding new light on how matrix properties influence cell phenotype and function.
Evaluation of a bilayered, micropatterned hydrogel dressing for full-thickness wound healing
Chelsea M. Magin, Dylan B. Neale, Michael C. Drinker, Bradley J. Willenberg, Shravanthi T. Reddy, Krista MD La Perle, Gregory S. Schultz and Anthony B. Brennan. 2016. Exp Biol Med (Maywood), 241(9): 986-95 (link)
Here, a bilayered, biodegradable hydrogel dressing that uses microarchitecture to guide two key steps in the proliferative phase of wound healing, re-epithelialization, and revascularization, was evaluated in vitro in a cell migration assay and in vivo in a bipedicle ischemic rat wound model. Collectively, the results demonstrate high potential for this new dressing to effectively accelerate wound healing.
Micropatterned Protective Membranes Inhibit Lens Epithelial Cell Migration in Posterior Capsule Opacification Model
Chelsea M. Magin, Rhea M. May, Michael C. Drinker, Kevin H. Cuevas, Anthony B. Brennan and Shravanthi T. Reddy. 2015. Translational Vision Science and Technology, 4(2): 1-8 (link)
A novel intraocular lens (IOL) incorporating the Sharklet (SK) micropattern in a membrane design surrounding the optic may help increase the success of cataract surgery by reducing secondary cataract, or posterior capsule opacification (PCO).
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