Our latest paper, a collaboration with Dr. Amy Ryan at the University of Southern California, presents a closer look at the state-of-the-art of iPSC differentiation for pulmonary engineering, offer evidence supporting the power of biomaterials to improve stem cell differentiation, and discuss our perspective on the potential for tissue-informed biomaterials to transform pulmonary regenerative medicine. … Continue reading Engineering Tissue-Informed Biomaterials to Advance Pulmonary Regenerative Medicine
The Magin Lab is thrilled to share our latest publication on hybrid-hydrogels for modeling fibrotic diseases in vitro. This international collaboration was led by Cassandra Petrou and includes colleagues from Lund University in Sweden. It was also featured on the cover of the Themed Issue: Emerging Investigators 2020 of the Journal of Materials Chemistry B. … Continue reading Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro
Precision-cut lung slices are very thin slices of lung tissue that can be kept alive in culture outside of the body and studied as a model for a variety of chronic pulmonary diseases. Unfortunately, slices alone are only viable for about a week, which is not enough time to study disease mechanisms and treatment. The … Continue reading Embedding of Precision-Cut Lung Slices in Engineered Hydrogel Biomaterials Supports Extended Ex Vivo Culture
Duncan Davis-Hall, MS; Vy Nguyen, BS; Tyler D’Ovidio, BS; Ethan Tsai, PhD; Ganna Bilousova, PhD; and Chelsea M. Magin, PhD https://doi.org/10.1002/adbi.201900022 Check out the Magin Lab’s first primary research article, published recently in Advanced Biosystems and featured on the journal’s cover! This is the culmination of Duncan Davis-Hall’s work as a Master’s student in … Continue reading Peptide-functionalized hydrogels modulate integrin expression and stemness in adult human epidermal keratinocytes
Our review in APJ-Lung highlights how advances in lung tissue characterization reveal dynamic changes in the structure, mechanics and composition of the extracellular matrix in chronic pulmonary diseases, and how this information paves the way for tissue-informed engineering of more organotypic models of human pathology. We envision that engineering strategies using precision biomaterials and advanced … Continue reading Publication: Tissue-Informed Engineering Strategies for Modeling Human Pulmonary Diseases
We are excited to announce that this week Ethan and Vy started synthesizing new materials!